Lack of lymphatic vessel phenotype in LYVE‐1/CD44 double knockout mice
Identifieur interne : 006627 ( Main/Exploration ); précédent : 006626; suivant : 006628Lack of lymphatic vessel phenotype in LYVE‐1/CD44 double knockout mice
Auteurs : Mai X. Luong [États-Unis] ; Joshua Tam [États-Unis] ; Qingcong Lin [États-Unis] ; Jeroen Hagendoorn [États-Unis, Pays-Bas] ; Kathryn J. Moore [États-Unis] ; Timothy P. Padera [États-Unis] ; Brian Seed [États-Unis] ; Dai Fukumura [États-Unis] ; Raju Kucherlapati [États-Unis] ; Rakesh K. Jain [États-Unis]Source :
- Journal of Cellular Physiology [ 0021-9541 ] ; 2009-05.
Abstract
Lymphatic vessels play a key role in maintaining tissue‐fluid homeostasis, immune surveillance and metastasis. The hyaluronan receptor, LYVE‐1, is widely used as a molecular marker for adult and embryonic lymphatic endothelium, but its physiological functions have not yet been established in vivo. In agreement with a recent report, LYVE‐1−/− mice, which are healthy and fertile, do not display any defects related to congenital abnormalities of the lymphatic system. One hypothesis for the absence of a phenotype in LYVE‐1 null mice is that other hyaluronan receptors, such as CD44, may compensate for LYVE‐1. To test this hypothesis, we created LYVE‐1/CD44 double knockout mice with appropriate littermate controls. Lymphatic vessel structure and function, as determined by histological methods and intravital microscopy, show that LYVE‐1−/−, CD44−/− and LYVE‐1−/−/CD44−/− mice are indistinguishable from wild‐type mice under normal conditions. Furthermore, resolution of carrageenan‐induced paw edema is comparable in all genotypes. However, LYVE‐1−/−/CD44−/− mice exhibit increased edema formation in a carrageenan‐induced paw inflammation model compared to wild‐type mice, but not to LYVE−/− or CD44−/− mice. These data suggest that LYVE‐1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE‐1 in inflammation. J. Cell. Physiol. 219: 430–437, 2009. © 2009 Wiley‐Liss, Inc.
Url:
- https://api.istex.fr/document/43406FCD0C22975E24F4CEC8596CA244EA8D546F/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665001
DOI: 10.1002/jcp.21686
Affiliations:
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<front><div type="abstract" xml:lang="en">Lymphatic vessels play a key role in maintaining tissue‐fluid homeostasis, immune surveillance and metastasis. The hyaluronan receptor, LYVE‐1, is widely used as a molecular marker for adult and embryonic lymphatic endothelium, but its physiological functions have not yet been established in vivo. In agreement with a recent report, LYVE‐1−/− mice, which are healthy and fertile, do not display any defects related to congenital abnormalities of the lymphatic system. One hypothesis for the absence of a phenotype in LYVE‐1 null mice is that other hyaluronan receptors, such as CD44, may compensate for LYVE‐1. To test this hypothesis, we created LYVE‐1/CD44 double knockout mice with appropriate littermate controls. Lymphatic vessel structure and function, as determined by histological methods and intravital microscopy, show that LYVE‐1−/−, CD44−/− and LYVE‐1−/−/CD44−/− mice are indistinguishable from wild‐type mice under normal conditions. Furthermore, resolution of carrageenan‐induced paw edema is comparable in all genotypes. However, LYVE‐1−/−/CD44−/− mice exhibit increased edema formation in a carrageenan‐induced paw inflammation model compared to wild‐type mice, but not to LYVE−/− or CD44−/− mice. These data suggest that LYVE‐1 and CD44 are not required for the formation or function of lymphatics, but do not rule out a role for LYVE‐1 in inflammation. J. Cell. Physiol. 219: 430–437, 2009. © 2009 Wiley‐Liss, Inc.</div>
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